03/2026

imAgeScore, a Cell Painting-Based Predictor of Cellular Age for High-throughput Drug Screening Applications

 

Eleni Patili^‡, Fabio M D’Orazio^‡, Jack Brelstaff, Koby Baranes, Rodrigo L dos Santos, Mark RN Kotter, Joana M Tavares

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Quantifying cellular age in vitro in a scalable and biologically meaningful manner is essential for the discovery of pharmacological interventions that modulate aging. We developed imAgeScore, a machine-learning model trained on high-content Cell Painting features to predict the phenotypic age of primary human dermal fibroblasts. imAgeScore correlates with chronological and DNA methylation–based age estimates and captures coordinated morphological… Continue reading:

 

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08/2023

clock.bio’s mission is to extend health span by 20 years based on biomarkers of ageing in a Phase 3 trial by the end of this decade

 

08.2023

Koby Baranes and Mark RN Kotter

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Ageing is considered an invariable reality of life and the root cause of mortality. For millennia humanity has dreamed of escaping its effects. Apart from maintaining a youthful state, there are good reasons for wanting to control the ageing process: ageing is the common risk factor for some of the deadliest diseases, including cancer, heart attack, and stroke. It underpins degenerative conditions such as Alzheimer’s, arthritis, and diabetes, which severely affect our quality of life. Age may in fact be considered the underlying disease and cause of these conditions. Continue reading: